Inlfuences of Resveratrol on the Proliferation of Cholangiocarcinoma Cells and Expression of p21 and

• 作 者: Liu Yong Qian Huaxiang Zhuo Ma
• 机 构: Medical 0ncology Department,Department of Internal Medicine
• 出 处: 国际转化医学杂志（英文版）
• 发表日期: 2004年期
• 关键词: Resveratrol Cholangiocarcinoma Proliferation p21 p27

Objective:To explore the effects of resveratrol on the proliferation of cholangiocarcinoma cells and expression of p21 and p27 proteins. Methods:The influences of resveratrol on the proliferation of cholangiocarcinoma cells and expression of p21 and p27 proteins were detected by methyl thiazolyl tetrazolium (MTT) method and Western blotting method, respectively. Results:Resveratrol had a conspicuous inhibitory effect on the proliferation of cholangiocarcinoma QBC939 cells, and was concentration-and time-dependant (P < 0.05). In addition, it could up regulate the expression of p21 and p27 proteins obviously, and was concentration-dependant (P