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目的 :观察不同预后 (透析组、非透析组 ) Ig A肾病患者肾间质内层粘连蛋白 (L N)与纤维连接蛋白(FN)的局部沉积 ,探讨其与 Ig A肾病长期预后的关系。方法 :应用单克隆抗体免疫组织化学酶标法对确诊为Ig A肾病患者的肾组织进行染色 ,依据沉积类型并按半定量方法结合病情进行分析。结果 :L N和 FN沉积模式与疾病预后无关 ,L N的沉积量亦与预后无关 ,而 FN在透析组患者和非透析组患者沉积量有显著差异 (P<0 .0 0 1)。结论 :肾间质中 FN的沉积量增加是 Ig A肾病患者预后不良的重要因素。
OBJECTIVE: To observe the local deposition of laminin (LN) and fibronectin (FN) in IgA nephropathy patients with different prognosis (dialysis group, non-dialysis group), and to explore its relationship with the long-term prognosis of IgA nephropathy. Methods: The renal tissues of patients diagnosed as Ig A nephropathy were stained with monoclonal antibody immunohistochemistry and analyzed according to the types of sedimentation and according to the semi-quantitative methods. Results: The deposition pattern of L N and FN was not related to the prognosis of the disease. The deposition of L N was also independent of the prognosis. However, there was a significant difference in the deposition of FN among dialysis patients and non-dialysis patients (P <0.01). Conclusion: The increased deposition of FN in the interstitium is an important factor in the poor prognosis of patients with IgA nephropathy.