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本研究对脑肿瘤手术前后血浆内皮素－１含量变化进行了研究和分析。方法：采用均相放射免疫竞争方法直接测定３７例脑肿瘤患者和２４例对照血浆ＥＴ－１含量。结果：脑瘤患者浆ＥＴ－１含量为７１．０１４％ｐｇ／ｍｌ，比对照组５３．３５２ｐｇ／ｍｌ和标准值５０．８ｐｇ／ｍｌ高，有统计学意义。术后第二天血浆ＥＴ－１含量比术前和术后第八天低，术后第八天比术前血浆ＥＴ－１含量低，均有统计学差异．脑膜瘤、胶质瘤和垂体瘤患者术前血浆ＥＴ－１含量均比对照组高，不同病理类型的脑肿瘤患者术后血浆ＥＴ－１与术前比较均下降，但无显著性差异。结论：ＥＴ－１除参与脑肿瘤的发生、发展和分化过程外，还参与手术前后脑血流的调节。
This study of brain tumor before and after surgery plasma endothelin-1 content changes were studied and analyzed. Methods: The content of plasma ET-1 in 37 patients with brain tumor and 24 patients in control group were determined by homogeneous radioimmunoassay. Results: The content of plasma ET-1 in brain tumor patients was 71.014% pg / ml, which was significantly higher than 53.352pg / ml in control group and 50.8pg / ml in standard value. The level of plasma ET-1 on the second postoperative day was lower than preoperative and postoperative eight days, and the eighth postoperative day was lower than preoperative plasma ET-1 levels. The plasma levels of ET-1 in patients with meningioma, glioma and pituitary tumor were higher than those in control group. The plasma levels of ET-1 in patients with different pathological types of brain tumor decreased compared with those before operation, but no significant difference was found. Conclusion: ET-1 is involved in the development of cerebral neoplasm, development and differentiation process, and is involved in the regulation of cerebral blood flow before and after surgery.