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目前对钙-钙调素(Calmoclulin,CaM)与遗传性高血压发病的关系报道很多。在对自发性高血压大鼠(SHR)的研究中,已证实钙代谢障碍主要表现在细胞内钙浓度及钙与膜的结合、转运、与CaM的结合和囊泡摄取等多环节的异常。由于红细胞膜具有除Na~+-Ca~(2+)交换以外的各种主动及被动的阳离子转运系统及99％的可交换钙都容纳在单一库内的双重优点,加之其取材方便,制备简单,因而我们对钙通道阻断剂心痛定治疗前后SHR红细胞膜Ca~(2+)-Mg~(2+)ATP酶,Mg~(2+)ATP酶活性进行了研究。
There are many reports on the relationship between Calmoclulin (CaM) and hereditary hypertension. In studies of spontaneously hypertensive rats (SHRs), it has been demonstrated that disorders of calcium metabolism are mainly manifested by intracellular calcium concentrations and abnormalities in many aspects of calcium-membrane binding, transport, binding to CaM, and vesicle uptake. Since the erythrocyte membrane has various active and passive cation transport systems other than Na ~ + -Ca ~ (2+) exchange and 99% exchangeable calcium are both accommodated in a single reservoir, and its convenient preparation, preparation Therefore, we investigated Ca ~ (2 +) - Mg ~ (2+) ATPase and Mg ~ (2+) ATPase activities of erythrocyte membrane in SHR before and after calcium channel blockers were treated with nifedipine.