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用MMX分子力学程序以及分子图形学方法对α-氨基膦酸酯与N-氯乙酰基甘氨酸乙酯反应的机理进行了探讨。结果表明,此类反应热力学因素不起主要作用,动力学因素起主要作用,取代基空间效应是影响反应历程的重要因素。
The mechanism of the reaction of α-aminophosphonate with N-chloroacetylglycine ethyl ester was studied by MMX molecular mechanics program and molecular graphic method. The results show that the thermodynamic factors of such reactions can not play a major role, and the kinetic factors play a major role. The space effect of substituents is an important factor affecting the reaction process.