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探讨叶氏养胃汤对环磷酰胺(Cy)所致血小板减少的影响。采用腹腔注射环磷酰胺造模,实验分为6组:空白对照组,模型对照组,阳性对照组,叶氏养胃汤高、中、低剂量组,每组12只,空白对照组、模型对照组灌胃生理盐水、阳性对照组皮下注射重组人血小板生成素注射液,叶氏养胃汤各剂量组灌胃叶氏养胃汤,连续灌胃14 d。分别于灌胃第7、14d后各组小鼠断尾取血,测定血小板含量,观察叶氏养胃汤对Cy引起血小板降低的影响。结果表明:从第7天灌胃叶氏养胃汤组开始叶氏养胃汤各剂量组小鼠血小板明显高于模型对照组(P<0.05,P<0.01)。叶氏养胃汤对环磷酰胺(Cy)所致小鼠血小板降低具有明显的保护作用。
To investigate the effect of YeShiYangWeiTang on thrombocytopenia induced by cyclophosphamide (Cy). The rats were divided into 6 groups by blank intraperitoneal injection of cyclophosphamide: blank control group, model control group, positive control group, Yip’s Yangwei Decoction high, medium and low dose groups, 12 in each group, blank control group, model The control group was given normal saline, and the positive control group was subcutaneously injected with recombinant human thrombopoietin injection. Each dose group of Ye’s Yangwei Decoction was administered with Ye’s Yangwei Decoction for 14 days. Blood samples were taken from the tail of the mice on the 7th and 14th day after gavage, respectively. The platelet content was measured and the influence of Yip’s Yangwei Decoction on Cy-induced thrombocytopenia was also observed. The results showed that the platelet count of mice in each dose group of YEJI group was obviously higher than that of the model control group (P <0.05, P <0.01). YeShiYangWeiTang cyclophosphamide (Cy) induced thrombocytopenia in mice has a significant protective effect.