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目的 :探讨小剂量高渗氯化钠 (HS)和复方高渗醋酸钠 (HSA)复苏对海水浸泡失血性休克大鼠的治疗效果。方法 :应用海水浸泡失血性休克大鼠模型 ,以生理盐水 (NS)为对照组 ,观察小剂量HS和HSA对其动脉血气的影响。结果 :NS组 30min后动脉血 pH降低、BE -B、HCO3 显著降低 ,PCO2 显著升高 ,而HS组和HSA组动脉血pH升高 ,BE -B、HCO3 、血压比对照组好 ,PCO2 也低於NS组 ,存活时间延长 ,血浆Cl-浓度HSA组低于HS组 (P <0 .0 5 )。结论 :HS和HSA对失血性休克早期复苏效果较好 ,HSA能更有效地升压、稳压、稳定酸碱平衡、减轻高氯酸血症、纠正酸中毒。
Objective: To investigate the therapeutic effect of low dose hypertonic sodium chloride (HS) and compound hypertonic sodium acetate (HSA) resuscitation on rats with seawater immersion hemorrhagic shock. Methods: The rat model of hemorrhagic shock was immersed in seawater. NS was used as the control group to observe the effect of low dose HS and HSA on arterial blood gas. Results: In the NS group, arterial blood pH decreased, BE-B and HCO3 decreased significantly, and PCO2 increased significantly after 30min in the NS group. In the HS group and HSA group, arterial blood pH increased, BE-B, HCO3 and blood pressure were higher than those in the control group In NS group, survival time was prolonged and plasma Cl-concentration in HSA group was lower than that in HS group (P <0.05). Conclusions: HS and HSA are effective in early resuscitation of hemorrhagic shock. HSA can more effectively boost blood pressure, regulate blood pressure, stabilize acid-base balance, relieve hyperchloraemia and correct acidosis.