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目的探索防治结核性胸膜炎胸膜肥厚成本低、效果好的治疗方法。方法64例中至大量游离结核性胸腔积液患者随机分为治疗组和对照组。治疗组胸腔置管完全引流积液后注入透明质酸钠,对照组常规胸穿抽液。统计治疗3个月后2组花费的成本,进行成本效果分析及敏感度分析。结果59例患者参与最后结果分析。治疗3个月后治疗组、对照组胸膜肥厚发生率是6.7%、31.0%(有效率分别是:93.3%、69.0%)(P<0.05);成本效果比(C/E)是35.19,47.53,敏感度分析显示C/E35.63,49.00。结论胸腔置管联合透明质酸钠防治结核性胸膜炎胸膜肥厚是成本低、效果好的方法。
Objective To explore the prevention and treatment of tuberculous pleurisy pleural hypertrophy and low cost, effective treatment. Methods A total of 64 patients with free tuberculous pleural effusion were randomly divided into treatment group and control group. In the treatment group, sodium hyaluronate was infused into the thoracic cavity after complete draining of effusion, and the control group received conventional chest draining fluid. After 3 months of treatment, the cost of the two groups was calculated, and cost-effectiveness analysis and sensitivity analysis were performed. Results 59 patients participated in the final result analysis. The incidence of pleural hypertrophy in the treatment group and control group after 3 months of treatment was 6.7% and 31.0% (effective rates were 93.3% and 69.0%, respectively) (P <0.05). The cost-effectiveness ratio (C / E) was 35.19 and 47.53 Sensitivity analysis showed C / E 35.63, 49.00. Conclusion Thoracic tube insertion combined with sodium hyaluronate in prevention and treatment of pleural thickening of tuberculous pleurisy is a low cost and effective method.