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目的对质子泵抑制药在非糜烂性食管反流病(NERD)的疗效进行分析。方法 64例NERD患者,随机分为对照组与观察组,各32例。对照组接受法莫替丁治疗,观察组在对照组基础上加用埃索美拉唑治疗,对比两组临床疗效。结果观察组治疗总有效率显著高于对照组(P<0.05),两组患者不良反应发生率比较差异无统计学意义(P>0.05),且经治对症处理后不良反应症状均消失。结论在NERD治疗中,应用质子泵抑制药疗效显著,可大幅改善患者临床症状,有效提高患者生存质量,值得在临床中推广。
Objective To analyze the efficacy of proton pump inhibitors in non-erosive esophageal reflux disease (NERD). Methods 64 patients with NERD were randomly divided into control group and observation group, 32 cases in each. The control group received famotidine. The observation group was treated with esomeprazole on the basis of the control group, and the clinical efficacy was compared between the two groups. Results The total effective rate in the observation group was significantly higher than that in the control group (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). The symptoms of adverse reactions disappeared after treatment. Conclusion In the NERD treatment, the application of proton pump inhibitor has significant curative effect, which can significantly improve the clinical symptoms and effectively improve the quality of life of patients, which is worth to be popularized in clinic.