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目的探讨苄星青霉素与皮肤物理抗菌膜联合应用治疗梅毒硬下疳患者的临床疗效。方法选取2015年3月至2016年6月于辽宁省沈阳维康医院接受诊治的92例梅毒硬下疳患者作为研究对象,根据抛硬币法进行分组,正面为对照组,反面为试验组,各46例。对照组患者接受苄星青霉素治疗,试验组患者则在对照组基础上接受皮肤物理抗菌膜治疗,比较两组患者治疗后皮损愈合情况、临床效果、不良反应发生率以及血清白细胞介素-27(IL-27)和白细胞介素-33(IL-33)变化情况。结果治疗1周、2周、3周及1个月,试验组患者皮损愈合率均明显高于对照组,差异均有统计学意义(均P<0.05);试验组患者治疗的总有效率(95.7%)显著高于对照组(65.2%),不良反应发生率(8.7%)显著低于对照组(30.4%),差异均有统计学意义(均P<0.05);治疗后,试验组患者血清IL-27和IL-33水平均明显低于对照组,差异均有统计学意义(均P<0.05)。结论采用苄星青霉素联合皮肤物理抗菌膜治疗梅毒硬下疳临床效果显著。
Objective To investigate the clinical efficacy of combination of benzathine penicillin and skin antimicrobial film in the treatment of patients with syphilis. Methods From March 2015 to June 2016, 92 cases of syphilitic subdural patients admitted to Weikang Hospital of Shenyang, Liaoning Province were selected as the research object, grouped according to the coin-tossing method, the positive control group and the negative experimental group example. The patients in the control group were treated with penicillin. The patients in the test group were treated with skin antimicrobial film on the basis of the control group. The healing of skin lesions, the clinical effect, the incidence of adverse reactions and the serum interleukin-27 (IL-27) and interleukin-33 (IL-33) changes. Results The healing rates of skin lesions in test group were significantly higher than those in control group at 1 week, 2 weeks, 3 weeks and 1 month after treatment (all P <0.05). The total effective rate of treatment (95.7%) was significantly higher than the control group (65.2%), the incidence of adverse reactions (8.7%) was significantly lower than the control group (30.4%), the difference was statistically significant The levels of serum IL-27 and IL-33 in patients were significantly lower than those in control group (all P <0.05). Conclusion The clinical effect of using penicillin combined with skin physical antimicrobial film in the treatment of syphilis is significant.