论文部分内容阅读
本文将中药复方复聪片及方内补肾、活血祛瘀、益气养血、通窍聪耳等主药分别进行治疗豚鼠庆大霉素（GM）耳中毒的观察。豚鼠每日肌注庆大霉素100mg／kg2次，共8日，耳廓反射消失后，喂服复聪片及各拆方组药物30日。采用测定治疗前后听觉脑干诱发电位（ABR）阈值，耳蜗铺片外毛细胞观察计数，血管纹观察，耳蜗超微结构电镜观察等方法，结果证实复聪片及方中活血祛瘀药物可促使受损毛细胞、血管纹形态及功能恢复，有效降低庆大霉素耳中毒豚鼠听阈，阻止庆大霉素停药后迟发的听阈升高。说明复聪片对庆大霉素所致药物中毒性聋有一定的治疗作用。
This article will observe the gentamicin (GM) ototoxicity in guinea pigs treated with the traditional Chinese medicine compound Fusong tablets, and the main drugs including Fangshen Bushen, Huoxuejing, Qiqiyangxuexue, and Tongqiao Congying. Guinea pigs received intramuscular injection of gentamycin 100 mg/kg twice a day for 8 days. After the auricle reflex disappeared, the patients were fed with Fushun tablets and each group of decontamination drugs for 30 days. The thresholds of auditory brainstem evoked potential (ABR) before and after treatment, the observation of outer hair cells in the cochlea prosthesis, the observation of vascular striae, and the electron microscopy of the ultrastructure of the cochlea were used to determine the efficacy of Fusong tablets and Fangzhong Huoxue medication. The recovery of damaged hair cells and vascular striae morphology and function effectively reduced the hearing threshold of gentamicin ototoxic guinea pigs and prevented the increase of hearing threshold after gentamycin withdrawal. It shows that Fucong Tablets have a certain therapeutic effect on gentamicin-induced drug toxicity.