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人外周血淋巴细胞介导针对致敏前未明确的各种靶细胞的细胞毒性。与这种活性有关的效应细胞的异质群统称为“自然杀伤细胞”。人自然杀伤细胞的特钲是不粘附塑料表面,虽然有 IgG 的 Fc 受体,但缺乏表面免疫球蛋白,而且无 E 花环形成,自然杀伤细胞至少有三种功能,即造血的调节作用,防御病毒感染和监视肿瘤。近来揭示自然杀伤细胞与内白细胞溶菌素(interleukin)-2和干扰素配合不仅在防止肿瘤发生方面,而且在全身免疫监视系统中起重要作用。为了阐明妊娠期自然杀伤细胞活性,作者研究了妊娠毒血症、正常孕妇和产褥期妇女,用高度敏感的 K562肿瘤细胞株作靶细胞。结果表明早孕期自然杀伤细胞活性比非孕妇低但无明显统计学差异。到孕中,晚期抑制变为明
Human peripheral blood lymphocytes mediate cytotoxicity against various target cells that have not been clearly sensitized before. The heterogeneous group of effector cells associated with this activity is called “natural killer cells.” Although natural killer cells do not adhere to plastic surfaces, there is a lack of surface immunoglobulins and no E-rosette formation despite IgG Fc receptors. Natural killer cells have at least three functions, namely, hematopoietic regulation, defense Virus infection and surveillance of tumors. It has recently been revealed that natural killer cells cooperate with interleukin-2 and interferons not only play an important role in preventing tumorigenesis, but also in the systemic immune surveillance system. To clarify the activity of natural killer cells during pregnancy, the authors studied gestational toxemia, normal pregnant women, and puerperium women using highly sensitive K562 tumor cell lines as target cells. The results showed that natural killer cells in early pregnancy activity than non-pregnant women, but no significant difference. To pregnancy, late suppression becomes clear