【摘 要】
：
目的 基于国内已上市的四家胶体金法新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-COV-2)抗体检测试剂,分析患者抗体动态变化及其与疾病严重程度的关系,了解患者免疫应答情况及胶体金试剂的临床诊断效能.方法 应用国内已上市的四家胶体金法抗体检测试剂盒检测2020年1月21日—4月11日在广州医科大学附属市八医院住院的60例(其中48例轻症,12例重症)新冠肺炎患者的290份血浆标本,操作步骤按照试剂盒说明书严格进行,分析评判4种胶体金
【机 构】
：
广州医科大学附属市八医院传染病研究所,广东广州 510060;广州医科大学附属市八医院感染科,广东广州 510060
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目的 基于国内已上市的四家胶体金法新型冠状病毒(severe acute respiratory syndrome coronavirus 2,SARS-COV-2)抗体检测试剂,分析患者抗体动态变化及其与疾病严重程度的关系,了解患者免疫应答情况及胶体金试剂的临床诊断效能.方法 应用国内已上市的四家胶体金法抗体检测试剂盒检测2020年1月21日—4月11日在广州医科大学附属市八医院住院的60例(其中48例轻症,12例重症)新冠肺炎患者的290份血浆标本,操作步骤按照试剂盒说明书严格进行,分析评判4种胶体金法抗体检测试剂的临床诊断性能.结果 新型冠状病毒肺炎(新冠肺炎)患者抗体阳性率在发病早期有随病程延长而呈逐渐升高趋势,发病第1周内患者的阳性率为19.23％～34.62％,第2周和第3周内患者的抗体阳性率分别为52.27％～68.18％和83.05％～98.31％.IgM抗体阳性率在发病第4周达到峰值,之后第5～6周后表现出下降趋势,至第9周显著下降.但IgG抗体阳性率在两个月的观察期内没有显著降低;轻症和重症患者抗体阳性率差异无统计学意义,P＞0.05;四家试剂对60例患者的诊断灵敏度为78.33％～91.67％;最高和最低值相比,差异有统计学意义,x2=4.183,P=0.041.结论 胶体金法抗体试剂检测新冠肺炎患者的抗体阳性率早期较低,晚期升高;抗体阳性率与疾病严重程度没有相关性;不同的试剂检测灵敏度存在一定的差异.
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