Calorimetric study on thermally-induced conformational change of dihydrofolate reductase

• 作 者: 刘云娜 谈夫
• 机 构: Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China,Institute of Chemistry, C
• 出 处: Chinese Science Bulletin
• 发表日期: 1996年21期
• 关键词: conformational thermally potent anticancer reversible reductase calorimetry occa

Dihydrofolate reductase(DHFR)(EC 1.5.1.3)exists in all biobodies.It is an importantcomponent of the chemistry of DNA synthesis in cells.Methotrexate,a potent inhibitor ofDHFR,is a well-known anticancer agent.It has been employed extensively in clinicaltreatment.Therefore,the study on the conformational change of DHFR gives occasion topeople’s close attention.The thermally-induced conformational change of DHFR was

Dihydrofolate reductase (DHFR) (EC 1.5.1.3) exists in all biobodies. It is an important component of the chemistry of DNA synthesis in cells. Methotrexate, a potent inhibitor of DHFR, is a well-known anticancer agent. It has been employed extensively in clinicaltreatment.Therefore, the study on the conformational change of DHFR gives occasion topeople’s close attention. The thermally-induced conformational change of DHFR was