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目的 :探讨 COX- 2在胃癌中的表达及其与胃癌血管生成的关系。方法 :用免疫组化 SP法检测 45例胃癌、癌旁组织 COX- 2和微血管密度 ( MVD)的阳性表达。结果 :胃癌组织 COX- 2的阳性表达率 ( 77.78% )和 MVD( 5 8.1 3± 1 9.99)明显高于癌旁组织 ( 33.33% ,2 4 .0 2± 1 0 .2 8,P<0 .0 1 ,P<0 .0 5 )。36例有局部淋巴结转移者 COX- 2阳性表达率和MVD明显高于无转移者 ( 86.1 1 % vs 44.44% ,5 8.60± 1 8.2 4 vs 43.5 4± 1 5 .0 5 ,P<0 .0 5 ,P<0 .0 5 ) ;浸润达浆膜层者 COX- 2阳性表达率和 MVD明显高于未达浆膜层者 ( 87.88%vs 5 0 .0 % ,5 7.0 1± 1 8.79vs 42 .35± 1 4.65 ,P<0 .0 5 ,P<0 .0 5 )。COX- 2 ( + )组 MVD( 61 .2 9± 1 4.31 )显著高于 COX- 2 ( - )组 ( 4 5 .38± 1 2 .42 ,P<0 .0 5 ) ,COX- 2与 MVD显著正相关( P<0 .0 1 )。结论 :COX- 2与胃癌的发生及侵袭、转移有关 ;可能通过参与胃癌血管生成 ,促进胃癌的发生发展
Objective: To investigate the expression of COX-2 in gastric cancer and its relationship with angiogenesis in gastric cancer. Methods: Immunohistochemical SP method was used to detect the positive expression of COX-2 and microvessel density (MVD) in 45 cases of gastric cancer and paracancerous tissues. Results: The positive expression rates of COX-2 in gastric cancer tissues (77.78%) and MVD (5 8.13 ± 1.99.99) were significantly higher than those in adjacent tissues (33.33%, 24.02 ± 1.08, P <0 .0 1, P <0. 0 5). The positive rates of COX-2 and MVD in 36 cases with local lymph node metastasis were significantly higher than those without metastasis (86.1 1% vs 44.44%, 5 8.60 ± 1 8.24 vs 43.5 4 ± 15.05, P <0. 0 5, P <0.05). The positive rates of COX-2 expression and MVD in infiltrating serosa were significantly higher than those in sub-serosa (87.88% vs 50.0%, 5 7.01 ± 1 8.79 vs 42.35 ± 1.65, P <0.05, P <0.05). MVD (61.29 ± 1.43) in COX-2 (+) group was significantly higher than that in COX-2 (-) group (45.38 ± 1.42.4, P <0.05) MVD was significantly correlated (P <0.01). Conclusion: COX-2 is associated with the occurrence, invasion and metastasis of gastric cancer. It may promote the development of gastric cancer by participating in the angiogenesis of gastric cancer