论文部分内容阅读
Zn-DTPA 是促排体内超铀元素的有效络合剂。对各种络合剂的一个重要的要求是在所用剂量范围内,对男人、妇女或后代都是安全的。本实验的目的是研究每天高剂量的 Zn-DTPA 对胎儿的致畸作用,并与 Ca-DTPA 进行比较。实验用 C57BL/Do 种小鼠,雌雄同笼后,每天早晨作阴道涂片,发现阴栓或在涂片上有精液时,确定为妊娠0天,与雄鼠隔离并进行分组。妊娠后第2～6或7～11天经皮下注射投药。Zn-DTPA 的剂量
Zn-DTPA is an effective complexing agent for promoting transuranic elements in the body. An important requirement for various complexing agents is that they are safe for men, women or offspring in the dosages used. The purpose of this experiment was to investigate the teratogenic effects of high doses of Zn-DTPA on the fetus and to compare with Ca-DTPA. Experimental C57BL / Do mice, male and female cage, vaginal smear every morning and found that when the suppository or semen on the smear, identified as pregnancy 0 days, isolated from the male and grouped. After pregnancy, 2 to 6 or 7 to 11 days by subcutaneous injection. The dose of Zn-DTPA