论文部分内容阅读
在5%Cu-5%Pd/γ-Al2O3催化剂作用下,由硝基苯和乙醇反应一锅法合成了2-甲基喹啉.实现了乙醇与硝基苯转移加氢、乙醛缩合、苯胺与不饱和醛加成、脱水环化、脱氢等多步反应的耦合.极大地简化了2-甲基喹啉的合成工艺.相比较传统的化学合成方法,由于避免了使用无机酸碱或均相金属络合物作为催化剂,该方法环境更加友好,解决了均相金属络合物催化剂分离、回收困难的问题.在优化的反应条件:使用1g催化剂,硝基苯15mL,乙醇60mL,水30mL,T=453K,P=3.5MPa,反应时间为12h时,2-甲基喹啉的收率达66.4%.
In the presence of 5% Cu-5% Pd / γ-Al2O3 catalyst, 2-methylquinoline was synthesized by one-pot reaction of nitrobenzene and ethanol. The transfer hydrogenation of ethanol and nitrobenzene, Aniline and unsaturated aldehyde addition, dehydration cyclization, dehydrogenation and other multi-step coupling reaction greatly simplifies the synthesis of 2-methylquinoline process.Compared to the traditional chemical synthesis method, as the use of inorganic acid-base Or homogeneous metal complex as a catalyst, the method is more friendly to the environment and solves the problem of difficult separation and recovery of the homogeneous metal complex catalyst.In the optimized reaction conditions, 1g of catalyst, 15mL of nitrobenzene, 60mL of ethanol, Water 30mL, T = 453K, P = 3.5MPa, the reaction time was 12h, the yield of 2-methylquinoline reached 66.4%.