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目的:探讨妊娠期肝内胆汁淤积症(intrahepatic cholestasis of pregnancy ICP)羊水性状与妊娠结局的关系。方法:对我院2005年1月～2009年12月住院分娩的患者资料进行回顾分析,统计羊水污染率、新生儿窒息发生率、围产儿死亡率及剖宫产率等。结果:347例ICP中轻度278例,重度69例。羊水污染89例(Ⅰ级19例,Ⅱ级14例,Ⅲ级56例),羊水污染率为25.6%。重度ICP中羊水污染46例,发生率为66.7%。89例ICP羊水Ⅱ级及Ⅲ级病例中出现3例新生儿窒息。结论:ICP的羊水性状与病情程度基本一致,羊水污染预示着不良的妊娠结局,适时终止妊娠可降低围生儿病率。
Objective: To investigate the relationship between amniotic fluid trait and pregnancy outcome in intrahepatic cholestasis of pregnancy ICP. Methods: The data of hospitalized patients from January 2005 to December 2009 in our hospital were retrospectively analyzed. The rates of amniotic fluid contamination, neonatal asphyxia, perinatal mortality and cesarean section rate were calculated. Results: There were 278 mild cases in 347 cases, and 69 cases were severe. Amniotic fluid pollution in 89 cases (Ⅰ grade 19 cases, Ⅱ grade 14 cases, Ⅲ grade 56 cases), amniotic fluid contamination rate was 25.6%. 46 cases of amniotic fluid contamination in severe ICP, the incidence was 66.7%. Three cases of neonatal asphyxia occurred in 89 cases of amniotic fluid grade Ⅱ and Ⅲ. Conclusion: The amniotic fluid trait of ICP is consistent with the severity of the disease. Amniotic fluid contamination indicates poor pregnancy outcomes. Terminating pregnancy timely can reduce the incidence of perinatal infection.