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探讨ＩＬ－６与不同类型脑肿瘤的相关性。方法：采用地高辛标记ＩＬ－６ｃＤＮＡ探针，运用原位杂交技术检测ＩＬ－６ｍＲＮＡ在４０例脑肿瘤组织中的表达。结果：在良、恶性肿瘤组表达率分别为２３．１％、７０．４％，恶性肿瘤组明显高于良性组，两组差异非常显著（Ｐ＜０．０１）．星形细胞瘤低分化组表达率大子高分化组，两组差异显著（Ｐ＜０．０５）。结论：结果表明ＩＬ－６ｍＲＮＡ表达率与肿瘤性质及星形细胞瘤的病理分级有关。提示ＩＬ－６可能对胶质细胞瘤的生长增殖有促进作用，对高分化的星形细胞瘤进一步向恶性发展可能有关系，测定血清ＩＬ－６对恶性肿瘤的预后判断有一定意义。
To investigate the correlation between IL-6 and different types of brain tumors. Methods: The digoxigenin-labeled IL-6 cDNA probe was used to detect the expression of IL-6 mRNA in 40 brain tumor tissues by in situ hybridization. Results: The expression rates in benign and malignant tumors were 23.1% and 70.4%, respectively, which were significantly higher in malignant tumors than in benign ones (P <0.01). Astrocytoma poorly differentiated group, the expression of large sub-high differentiation group, significant difference between the two groups (P <0.05). Conclusion: The results show that the expression of IL-6mRNA and the nature of the tumor and the pathological grade of astrocytoma. It is suggested that IL-6 may promote the growth and proliferation of glioma, and may be related to the malignant progression of well-differentiated astrocytoma. The determination of serum IL-6 has certain significance in the prognosis of malignant tumors.