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目的探讨汉族人群中血小板膜糖蛋白Ⅱb/Ⅲa基因多态性与脑梗死的关系。方法临床筛选121例实验病例,分为两组:脑梗死组75例,对照组46例。均提取基因组DNA,PCR扩增目的基因片段,并将扩增产物送生物公司测序,确定有无Ⅱb/Ⅲa基因多态性存在。最后进行统计学分析。结果在所有入选人群中仅发现1例脑梗死患者存在基因多态性,无临床及统计学意义。结论在汉族人群中,Ⅱb/Ⅲa基因多态性出现频率太低,与脑梗死发病无关。
Objective To investigate the relationship between polymorphism of platelet glycoprotein Ⅱb / Ⅲa gene and cerebral infarction in Han population. Methods 121 cases of clinical screening clinical trials, divided into two groups: 75 cases of cerebral infarction group, 46 cases of control group. Genomic DNA was extracted and the target gene fragment was amplified by PCR. The amplified product was sent to a biological company for sequencing, and the presence or absence of Ⅱb / Ⅲa gene polymorphism was found. Finally, statistical analysis. Results Only one patient with cerebral infarction was found in all enrolled patients, which had no clinical and statistical significance. Conclusion In Han population, the frequency of Ⅱb / Ⅲa gene polymorphism is too low, which has no relation with the incidence of cerebral infarction.