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用免疫组化方法检测了２７例肝细胞肝癌患者癌组织Ｐ５３及ｎｍ２３基因异常表达，结果Ｐ５３及ｎｍ２３基因异常表达率分别为６６．６７％和５９．２６％。Ｐ５３及ｎｍ２３基因异常表达与患者血清ＡＦＰ阳性有关（Ｐ＞０．０５），与存在门静脉癌栓有关（Ｐ＜０．０５）。提示Ｐ５３及ｎｍ２３基因异常表达与患者预后有关，对肝细胞肝癌患者检测Ｐ５３和ｎｍ２３基因可预测其预后。
The abnormal expression of P53 and nm23 genes was detected by immunohistochemistry in 27 cases of hepatocellular carcinoma. The abnormal expression rates of P53 and nm23 genes were 66.67% and 59.26%, respectively. The abnormal expression of P53 and nm23 genes was associated with positive serum AFP (P>0.05), and was associated with the presence of portal vein tumor thrombus (P<0.05). It is suggested that the abnormal expression of P53 and nm23 genes is related to the prognosis of patients. The detection of P53 and nm23 genes can predict the prognosis of patients with hepatocellular carcinoma.