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生长激素-胰岛素样生长因子(GH-IGF)轴对人体的生长发育起着重要的调控作用。对肢端肥大症病人的研究表明,GH-IGF轴对结直肠癌的发生和发展也起着重要的作用。重组人生长激素(rhGH)究竟能否应用于结直肠癌病人?阻断GH-IGF轴对结直肠癌病人是否有积极的治疗作用?这些都是目前广大学者关注的问题。现就GH-IGF轴与结直肠癌的关系作一综述。
The growth hormone-insulin-like growth factor (GH-IGF) axis plays an important regulatory role in human growth and development. Research on acromegaly patients shows that GH-IGF axis plays an important role in the occurrence and development of colorectal cancer. Whether recombinant human growth hormone (rhGH) can be applied to patients with colorectal cancer? Blocking the GH-IGF axis of colorectal cancer patients have a positive therapeutic effect? These are currently the majority of scholars concerned about the issue. The GH-IGF axis and colorectal cancer are reviewed.