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[目的]探讨非HBV感染型和HBV感染型原发性肝细胞癌病理学特征的差异。[方法]回顾性分析89例经手术切除并病理证实肝细胞性肝癌患者病理资料,包括肿块大小、病灶数目、包膜完整性、卫星灶、细胞分化程度及AFP、CD34、p53、Ki-67等免疫组化染色病理学特征与HBV感染的相关性,对各病理特征进行单因素χ2检验和多因素Logistic回归分析。[结果 ]89例患者中,25例为非HBV感染型,占28.09%。单因素分析显示,肿块大小、包膜完整性、卫星灶、细胞分化程度、AFP及CD34在HBV感染组和非感染组间差异有统计学意义;多因素Logistic分析结果显示,肿块大小(χ~2=10.360,P<0.01)、Edmondson分级(χ~2=6.671,P=0.01)、CD34(χ~2=6.671,P<0.05)及AFP(χ~2=7.638,P=0.01),两组间差异具有独立性。[结论 ]非HBV感染型较HBV感染型原发性肝细胞癌具有就诊时肿块较大和相对完整的包膜、较高的分化程度、CD34和AFP低表达等相对独特的病理特征。
[Objective] To investigate the difference of pathological features of non-HBV infection and HBV-infected primary hepatocellular carcinoma. [Methods] The clinical data of 89 patients with hepatocellular carcinoma confirmed by surgery and pathology were retrospectively analyzed. The tumor size, lesion number, completeness of capsule, satellite focus, cell differentiation and AFP, CD34, p53, Ki-67 And other immunohistochemical staining pathological features and HBV infection, the pathological features of single factor χ2 test and multivariate Logistic regression analysis. [Results] Of the 89 patients, 25 were non-HBV infection, accounting for 28.09%. Univariate analysis showed that the size of the tumor, the integrity of the envelope, the size of the satellite lesions, the degree of cell differentiation, AFP and CD34 were significantly different between HBV infected group and non-infected group. Multivariate Logistic analysis showed that the size of tumor (χ ~ 2 = 10.360, P <0.01), Edmondson classification (χ ~ 2 = 6.671, P = 0.01), CD34 (χ2 = 6.671, Differences between groups are independent. [Conclusion] Compared with HBV-infected primary hepatocellular carcinoma, non-HBV infected patients have relatively large and relatively complete envelopment, high differentiation, low expression of CD34 and AFP, and other relatively unique pathological features.