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在今年第38届日本妇产科年会上,鹿尔岛大学的鹈木等报告抗孕酮药(RU_(486))的抗着床作用研究,揭示了RU_(486)用作抗着床避孕药的可能性。 RU_(486)是在受体水平显示抗孕酮、抗皮质激素作用的合成甾体化合物,迄今看到的研究报告都是RU_(486)应用于中止早期妊娠和通过缩短黄体期的月经周期控制。为此,鹈木等给交配后的小鼠注射RU_(486),观察有无阻止受精卵在子宫内膜着床的作用,探讨了用作次晨片(morning-after pill)的可能性。方法:选用ICR系雌性小鼠,经PMS和HCG预处理后使之交配,在第2天早晨看到阴道栓时定
At the 38th Japan Obstetrics and Gynecology Annual Meeting, Kureha et al. Of Kureha University reported anti-implantation effects of antiprogestin (RU_ (486)) and revealed that RU_ (486) Possibility of birth control pills. RU 486 is a synthetic steroid compound that shows anti-progesterone and anti-corticosteroid effects at the receptor level. The studies reported so far have all reported that RU 486 should be used to halt early pregnancy and to control the menstrual cycle by shortening the luteal phase . For this purpose, Uruma et al. Injected the RU_ (486) mice after mating to observe the presence or absence of the fertilized egg in the implantation of the endometrium and to explore the possibility of using it as a morning-after pill. Methods: ICR female mice were selected and pretreated with PMS and HCG to make mating. When the vaginal suppository was seen in the morning of the second day