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Graves病甲状腺机能亢进症(简称甲亢)或毒性弥漫性甲状腺肿是一种自身免疫疾病。患者血清中有抗TSH—受体抗体,这类抗体具有兴奋甲状腺作用。抗受体抗体可能有两类:一类能促进甲状腺激素合成,即兴奋甲状腺免疫球蛋白(thyroid stimulating immunoglob-ulins,TSI),或称长效甲状腺刺激素(LATS);另一类促进甲状腺细胞增殖,称为促进甲状腺细胞生长的免疫球蛋白(thyroid growth im-munoglobulins,TGI),与甲状腺肿有关。这就可解释常见的甲亢伴有甲状腺肿,也有少数甲亢并无甲状腺肿,可能后者缺乏TGI。此外,
Graves disease Hyperthyroidism (hyperthyroidism) or toxic diffuse goiter is an autoimmune disease. Serum anti-TSH receptor antibodies, such antibodies have the role of excited thyroid. There are two possible types of anti-receptor antibodies: one is thyroid stimulating immunoglobulin (TSI), or long-acting thyroid stimulating hormone (LATS), which promotes thyroid hormone synthesis; the other is thyroid stimulating Proliferation, called thyroid growth im-munoglobulins (TGI), is associated with goiter. This can explain the common hyperthyroidism associated with goiter, but also a small number of hyperthyroidism without goiter, the latter may be the lack of TGI. In addition,