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目的:探讨妇女年龄对输卵管因素不孕体外受精-胚胎移植(IVF-ET)结局的影响。方法:回顾性分析2006年1月～2006年12月158例因单纯输卵管因素不孕在该院行IVF-ET助孕妇女的临床资料。根据妇女年龄分两组,组1(年龄<35岁)119例,组2(年龄≥35岁)39例。统计分析两组促排卵天数、促排卵药物(Gn)用量、获卵数、受精率、卵裂率、优质胚胎率、种植率、临床妊娠率及早孕流产率。结果:两组Gn用量、受精率、卵裂率、临床妊娠率差异无统计学意义(P>0.05)。组1获卵数、种植率比组2高,早孕流产率比组2低,差异有统计学意义(P<0.05)。结论:妇女年龄对IVF-ET结局有影响,年龄超过35岁获卵数下降,卵子质量下降,早孕流产率增高。
Objective: To investigate the influence of women’s age on the outcome of IVF-ET in tubal infertility. Methods: A retrospective analysis of 158 cases of simple oviduct infertility in the hospital from January 2006 to December 2006 in the IVF-ET clinical data of pregnant women. There were 119 cases in group 1 (age <35 years) and 39 cases in group 2 (age ≥35 years) according to women’s age. The number of ovulation induction days, ovulation induction drugs (Gn), number of oocytes retrieved, fertilization rate, cleavage rate, quality embryo rate, implantation rate, clinical pregnancy rate and early pregnancy miscarriage rate were statistically analyzed. Results: There was no significant difference in Gn dosage, fertilization rate, cleavage rate and clinical pregnancy rate between the two groups (P> 0.05). The number of oocytes in group 1 was higher than that in group 2, and the rate of abortion in early pregnancy was lower than that in group 2 (P <0.05). Conclusion: The age of women has an impact on the outcome of IVF-ET. The number of oocytes aged more than 35 years declines, the quality of the eggs decreases, and the rate of abortion in early pregnancy increases.