论文部分内容阅读
目的研究影响人脑胶质瘤预后的因素,为临床治疗提供理论依据。方法收集自2000年1月至2000年6月在南方医科珠江医院神经外科手术治疗的89例原发性星形细胞肿瘤病人的资料。生存分析单因素使用KaplanMeier法计算生存率并采用对数秩(Logrank)检验;多因素分析使用Cox比例风险模型,采用逐步回归分析。结果单因素分析结果显示年龄、术前机能状况(KPS)评分、术前癫痫、组织学分级、术后放疗等因素与患者预后有关(P<0.01);多因素分析示患者的年龄、术前KPS评分、组织学分级均为独立的预后因素,而术前癫痫、术后放疗则未显示出与预后有关。性别、肿瘤部位、肿瘤范围、手术治疗方式等因素两种分析均未发现与预后有关。结论患者年龄、术前KPS评分、组织学分级对预后影响较大;而术前癫痫史、术后放疗对判断预后价值有限;患者的性别、肿瘤部位和范围、手术治疗方式与预后无关。
Objective To study the factors affecting the prognosis of human glioma and provide a theoretical basis for clinical treatment. Methods A total of 89 patients with primary astrocytoma who underwent surgical treatment of neurosurgery in the Southern Medical Zhujiang Hospital from January 2000 to June 2000 were collected. Survival Analysis Univariate survival was calculated using the KaplanMeier method with a log rank test (Logrank); multivariate analysis was performed using the Cox proportional hazards model and stepwise regression analysis. Results The results of univariate analysis showed that age, preoperative KPS score, preoperative epilepsy, histological grade and postoperative radiotherapy were correlated with prognosis (P <0.01). Multivariate analysis showed that patients’ age, preoperative KPS score, histological grade were independent prognostic factors, and preoperative epilepsy, postoperative radiotherapy did not show the prognosis. Gender, tumor location, tumor size, surgical treatment and other factors were not correlated with prognosis. Conclusion The patient’s age, preoperative KPS score and histological grade have a great influence on the prognosis. However, preoperative epilepsy and postoperative radiotherapy have limited value in judging the prognosis. The gender, tumor location and scope, surgical treatment and prognosis have no relation with prognosis.