Adjuvant Effects of Dual Co-stimulatory Molecules on Cellular Responses to HIV Multiple-epitope DNA

• 作 者: SHEN Zhen-wei JIN Hong-tao LI
• 机 构: CollegeofAnimalScienceandVeterinaryMedicine,GeneticEngineeringLaboratory
• 出 处: 高等学校化学研究：英文版
• 发表日期: 2009年3期
• 关键词: 抗艾滋病毒 DNA疫苗 分子细胞 佐剂效应 多表位 T细胞反应 细胞毒性 病毒抗原 HIV DNA vaccine Co-stimulatory molecu
• 基金项目: Supported by the National High-tech Research and Development Program（No.2006AA02Z447）. We acknowledge LI Ping for cell culture, LI Jiping for purification of DNA vaccine, LI Xiao and CHEN Ya-jing for

Designing adjuvants that can induce strong cytotoxic T cell responses is largely required for preparing DNA vaccines. In this study we explored dual costimulatory molecules 4-1BBL and OX40L as adjuvants to improve the efficiency of the HIV multiple-epitop