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内皮脂酶(EL)由内皮细胞合成的三酰甘油脂肪酶家族成员。在内皮细胞表面发挥其生理作用,对个体高密度脂蛋白胆固醇(HDL-C)的水平及代谢有较为重要的影响作用。因为HDL-C是冠心病的重要保护因素之一,所以随着EL的深入研究对冠心病的病因及发病机制有更深层次的了解。国内外在EL的基因及其生理作用方面已有较多研究,但关于其与冠心病的病因及药物对EL影响方面的研究尚且不多,该文就EL的相关研究成果作一综述。
Endothelial lipase (EL) A member of the triacylglycerol lipase family synthesized by endothelial cells. Exert its physiological function on the surface of endothelial cells and have an important effect on the level and metabolism of individual high-density lipoprotein cholesterol (HDL-C). Because HDL-C is one of the important protective factors of coronary heart disease, so with the in-depth study of EL on coronary heart disease etiology and pathogenesis have a deeper understanding. At home and abroad, there are many studies on the gene and physiological function of EL, but there is not much research about the etiology of ELD and its influence on EL. The article reviewed the related research results of EL.