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血清高密度脂蛋白(HDL)是迄今唯一具有抗动脉粥样硬化(AS)作用的心脏保护性因子,HDL的水平与冠心病的发病率呈明显的负相关。HDL通过多种机制发挥其抗AS的作用,其中最为重要的是参与胆固醇的逆向转运,将胆固醇从外周血管壁等组织细胞中转运至肝脏并被清除,从而发挥其调节血胆固醇的水平、阻止巨噬细胞转化为泡沫细胞,以及防止胆固醇在血管壁中沉积的作用。本文主要综述了HDL及其亚类与冠心病的关系及以其为冠心病治疗靶点的相关进展。
Serum high density lipoprotein (HDL) is by far the only cardioprotective factor with anti-atherosclerosis (AS) effect. The level of HDL is negatively correlated with the incidence of coronary heart disease. HDL exerts its anti-AS action through a variety of mechanisms. The most important of these are involved in the reverse transport of cholesterol, which transports cholesterol from the peripheral vascular wall and other tissue cells to the liver and is cleared to exert its regulation of blood cholesterol level, Macrophages into foam cells, and preventing the deposition of cholesterol in the vessel wall. This article summarizes the relationship between HDL and its subclasses and coronary heart disease and its relative progress in the treatment of coronary heart disease.