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目的探讨美托洛尔对心肌梗死(AMI)患者心室晚电位和QT离散度(QTcd)的影响。方法将80例AMI患者随机分为对照组和治疗组。对照组予以消心痛、肠溶阿司匹林等药物,治疗组在常规治疗的基础上,服用美托洛尔50mg,2次/d,治疗6个月后测定心室晚电位(VLP)和QTcd及室性心律失常发生率,比较两组之间的差异。结果治疗组和对照组VLP分别占13.7%和38.7%,两组比较差异有统计学意义(χ2=20.05,P<0.01);治疗组和对照组QTcd分别为(34±11)ms和(71±24)ms,两组比较差异有统计学意义(t=4.248,P<0.05)。治疗组室性心律失常或心因性猝死的发生率明显减少(P<0.05,χ2=8.717)。结论美托洛尔能明显减少心肌梗死患者心室晚电位阳性率,降低QT离散度,预防心肌梗死患者恶性心律失常及猝死的发生。
Objective To investigate the effects of metoprolol on ventricular late potentials and QT dispersion (QTcd) in patients with myocardial infarction (AMI). Methods Eighty AMI patients were randomly divided into control group and treatment group. The patients in the control group were given heartburn and enteric-coated aspirin. The patients in the treatment group were treated with metoprolol 50mg twice daily for 6 months. The ventricular late potentials (VLP), QTcd and ventricular The incidence of arrhythmia was compared between the two groups. Results The VLP in the treatment group and the control group were 13.7% and 38.7% respectively, with significant difference between the two groups (χ2 = 20.05, P <0.01). The QTcd of the treatment group and the control group were 34 ± 11 ms and 71% ± 24) ms, the difference between the two groups was statistically significant (t = 4.248, P <0.05). The incidence of ventricular arrhythmia or sudden cardiac death in treatment group decreased significantly (P <0.05, χ2 = 8.717). Conclusion Metoprolol can significantly reduce the positive rate of ventricular late potentials in patients with myocardial infarction, reduce the QT dispersion and prevent the occurrence of malignant arrhythmias and sudden death in patients with myocardial infarction.