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目的探讨小剂量阿奇霉素治疗咳嗽变异性哮喘的疗效。方法咳嗽变异性哮喘患儿192例随机分为3组:A组吸入布地奈德;B组口服孟鲁司特;C组口服小剂量阿奇霉素。结果 A、B、C三组总有效率分别为89.7%、86.7%、90.0%,三组间差异无统计学意义(P>0.05)。结论小剂量阿奇霉素治疗儿童咳嗽变异性哮喘的临床疗效与吸入布地得奈德或口服孟鲁司特无明显差异,但患儿或其家长的治疗依从性明显优于吸入布地奈德或口服孟鲁司特两组患儿。
Objective To investigate the efficacy of low dose azithromycin in the treatment of cough variant asthma. Methods 192 children with cough variant asthma were randomly divided into 3 groups: group A inhaled budesonide; group B oral montelukast; group C oral low dose azithromycin. Results The total effective rates of A, B and C groups were 89.7%, 86.7% and 90.0%, respectively. There was no significant difference among the three groups (P> 0.05). Conclusions The clinical efficacy of low-dose azithromycin in the treatment of children with cough variant asthma is not significantly different from inhalation of brondenoid or oral montelukast, but the treatment compliance of children or their parents is significantly better than that of inhaled budesonide or oral montelukast Stuart two groups of children.