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结肠癌在临床较为常见,占消化道肿瘤的5%~8%,老年人较为多发,随着我国社会生活水平的逐步提高和生活节奏的加快,老年结肠癌发病率也呈现上升趋势,而结肠癌的耐药性往往严重影响治疗的效果,使得效果不尽如人意。髓样抑制细胞(MDSC)是一群来源于骨髓的幼稚细胞,具有很强的免疫抑制作用,是引起肿瘤免疫逃逸的重要细胞群。综述髓样抑制细胞在结肠癌耐药发生中影响机制的研究进展文献,并对其作了分析与展望。
Colon cancer is more common in clinical practice, accounting for 5% to 8% of gastrointestinal tumors, the elderly are more frequent, with the gradual improvement of social life and pace of life in China, the incidence of colon cancer also showed an upward trend, while the colon Cancer drug resistance is often severely affected the effect of treatment, making the effect is not satisfactory. Myeloid suppressor cells (MDSCs), a group of naive cells derived from bone marrow, have strong immunosuppressive effects and are important cell populations that cause tumor immune escape. This review summarizes the literature about the mechanism of myeloid-induced suppression of colon cancer drug resistance and analyzes and prospects it.