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多器官功能衰竭综合征（MOF）是临床治疗中出现的严重综合征，在颅脑疾病治疗过程中亦非少见。24例颅脑疾病住发MOF的分析结果表明，病死率达79．2％，衰竭器官依次为肺、肾、肝、胃肠、脑、胰、心、血液系统．病死率与受累器官数、年龄密切相关，而与GCS评分值无关．探讨了颅脑疾病伴发MOF的诊断标准、发生机理、治疗和预后，认为其有一定的独特性，尽管治疗MOF预后极差，但及时正确的处理是救治成功的关键．
Multiple organ failure syndrome (MOF) is a serious syndrome in clinical treatment, and is not uncommon in the treatment of craniocerebral diseases. Analysis of 24 cases of craniocerebral disease live-out MOF showed that the case fatality rate was 79.2%. The failing organs were lung, kidney, liver, gastrointestinal, brain, pancreas, heart and blood system in turn. The mortality was closely related to the organ number and age, but not to the GCS score. The diagnostic criteria, mechanism, treatment and prognosis of craniocerebral disease associated with MOF are discussed. It is considered to be unique. Although the treatment of MOF has very poor prognosis, timely and correct treatment is the key to successful treatment.