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在体外循环期间,病人发生重度肝素耐药性虽较为少见,然而出血和血栓的后果却常是灾难性的。对此现象至今尚缺乏了解。本文分析曾应用肝素病人的血浆肝素浓度、激活凝血时间(ACT)、肝素敏感性、抗凝血酶Ⅲ活性、纤维蛋白原、凝血因子和血小板计数,以探讨术前应用肝素对产生这一现象的影响。方法:46例成人患者分为两组:术前曾用肝素组8例(瓣膜换置7例、冠状动脉旁路术1例);术前未用肝素对照组38例,后者又分为两亚组,冠状动
Severe heparin resistance is less common in patients during cardiopulmonary bypass, but the consequences of bleeding and thrombosis are often catastrophic. To this phenomenon is still a lack of understanding. This article analyzes the heparin plasma heparin concentration, activation clotting time (ACT), heparin sensitivity, antithrombin III activity, fibrinogen, clotting factor and platelet count to explore the preoperative application of heparin to produce this phenomenon Impact. Methods: 46 adult patients were divided into two groups: 8 patients were treated with heparin (valve replacement in 7 and coronary artery bypass in 1); 38 patients without heparin control before operation were divided into Two subgroups, coronal