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p63转录因子的表达具有促进表皮发生和维持表皮正常分化的双重作用。在胚胎期表皮发生时,p63作为单层体表外胚层层化的分子开关;而在成熟表皮中,p63有维持基底层表皮干细胞增殖潜能的作用。
The expression of p63 transcription factor plays a dual role in promoting epidermal development and maintaining normal epidermis differentiation. In epidermal epidermis, p63 acts as a monolayer of surface epidermal ectoderm stratification of the molecular switch; whereas in mature epidermis, p63 maintains the basal layer of epidermal stem cell proliferation potential.