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目的:探讨卵巢低反应患者第2天或第3天移植的妊娠结局。方法:回顾性分析265个初始新鲜体外受精-胚胎移植(IVF-ET)周期,分别在第2天(n=169)或第3天(n=96)移植所有可利用胚胎而无冷冻胚胎患者的妊娠结局。结果:在<35岁的患者组中,第3天移植较第2天移植有更高的临床妊娠率(50.00%vs32.43%,相对危险度为0.65;95%CI为0.43～0.99)。结论:在≥35岁的卵巢低反应患者中,第2天或第3天移植有着相似的妊娠结局,缩短胚胎在体外培养时间对妊娠结局没有明显益处。而在年龄<35岁的患者中,第3天移植可能有更好的妊娠结局。
Objective: To investigate the outcome of pregnancy on day 2 or day 3 of patients with low ovarian response. METHODS: A total of 265 initial fresh in vitro fertilization-embryo transfer (IVF-ET) cycles were retrospectively analyzed and all available embryos were transplanted on day 2 (n = 169) or on day 3 Of pregnancy outcomes. Results: In the 35-year-old patient group, day 3 had a higher clinical pregnancy rate (50.00% vs 32.43%, relative risk 0.65; 95% CI 0.43 to 0.99) than day 2. CONCLUSIONS: Day 2 or day 3 transplants have similar pregnancy outcomes in ≥35-year-old patients with ovarian hyporesponsiveness, and shortening the embryo’s in vitro culture time has no significant benefit on pregnancy outcomes. In patients <35 years of age, the third day of transplantation may have better pregnancy outcomes.