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目的评价国产阿奇霉素针剂治疗呼吸道感染的临床疗效及其安全性。方法采用开放对照方法 ,将50例呼吸道细菌感染患者随机分为试验组和对照组。试验组给阿奇霉素针剂250mg·d-1,qd ,iv ,5d ,首剂加倍 ;对照组给头孢唑啉2g/次 ,bid,iv,5～10d。结果两组在综合临床疗效方面无显著差异 ;试验组痊愈率46.67 %,有效率为90 %、不良反应率3.3 %;对照组痊愈率60 %、有效率95 %、不良反应率0 %。结论国产阿奇霉素针剂用于呼吸道感染的治疗是有效、安全的。
Objective To evaluate the clinical efficacy and safety of domestic azithromycin in the treatment of respiratory tract infections. Methods 50 patients with respiratory tract bacterial infection were randomly divided into experimental group and control group by open control method. The experimental group to azithromycin injection 250mg · d-1, qd, iv, 5d, the first dose double; control group to cefazolin 2g / times, bid, iv, 5 ~ 10d. Results There was no significant difference between the two groups in comprehensive clinical efficacy. The cure rate was 46.67%, the effective rate was 90% and the adverse reaction rate was 3.3% in the experimental group. The cure rate in the control group was 60%, the effective rate was 95% and the rate of adverse reactions was 0%. Conclusion Domestic azithromycin injection for the treatment of respiratory tract infection is effective and safe.