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异搏停的血流动力学效应异搏停对循环系统的作用是其对心肌的直接作用以及通过其周围血管作用的反射性效应的相互影响的结果.在离体心肌,异搏停产生较重的负性变力效应,抑制心肌的兴奋性以及窦房结和房室结的传导性;这些抑制作用可被钙及儿茶酚胺所拮抗.异搏停亦可作用于血管的钙通道,使体循环及冠状动脉扩张.这些体循环血管扩张作用可反射性地引起交感兴奋,从而抵销药物对心肌的负性收缩及传导抑制作用.因此,异搏停对心肌的直接抑制作用主要在收缩及传导功能已有失常或交感兴奋被某些药物所减弱时,其表现才最为明显.
The effect of verapamil on hemodynamics The effect of verapamil on the circulatory system is the result of its direct effect on the myocardium and the interaction of the reflexive effects through its peripheral vasculature. Heavy negative variable effect, inhibit the excitability of the myocardium and the conduction of the sinus node and atrioventricular node; these inhibitory effect can be antagonized by calcium and catecholamines .When stroke with calcium can also act on the blood vessels, the systemic circulation And coronary artery dilatation.These vasoconstrictive vasodilative effect can cause sympathetic reflex reflex, which counteracts the negative contraction and conduction inhibition of the drug.Therefore, the direct inhibitory effect of verapamil on myocardium mainly in the contraction and conduction function Has been abnormal or sympathetic excitement was weakened by some drugs, its performance was the most obvious.