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目的探讨ras基因及AFP水平与肝癌病程的关系。方法测定50例病理检查确诊的肝癌患者血清AFP水平,并检测其手术切除肝癌组织中ras的表达,分析ras基因及血清AFP联合检测与肝癌有无远处转移及术后复发的关系。结果(1)ras在肝癌组织中阳性表达率为64.0%,ras表达与肿瘤大小、有无肝内转移密切相关(P<0.05)。ras阳性、阴性表达病例3年复发率分别为65.6%、33.3%。(2)高血清AFP水平且ras阳性病例组3年复发率为76.2%,而低血清AFP且ras阳性病例组3年复发率45.5%,差异显著(P<0.05)。结论联合ras基因及血清AFP检测可作为判断肝癌术后复发的有效指标,多因素分析更有价值。
Objective To investigate the relationship between ras gene and AFP levels and the course of hepatocellular carcinoma. Methods Serum AFP levels were determined in 50 patients with hepatocellular carcinoma confirmed by pathology. The expression of ras in the resected hepatocellular carcinoma tissues was detected. The relationship between ras gene and serum AFP levels and distant metastasis and recurrence of hepatocellular carcinoma was analyzed. Results (1) The positive expression rate of ras in hepatocellular carcinoma was 64.0%. The expression of ras was closely related to tumor size and intrahepatic metastasis (P <0.05). The three-year recurrence rates of ras positive and negative cases were 65.6% and 33.3% respectively. (2) The high-serum AFP level in ras-positive cases was 76.2% at 3 years, while the low-serum AFP and ras-positive cases were 45.5% at 3 years. The difference was significant (P <0.05). Conclusion Combined detection of ras gene and serum AFP can be used as an effective indicator to judge postoperative recurrence of liver cancer. Multivariate analysis is more valuable.