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目的探讨倍他乐克对急性冠脉综合征患者自主神经功能的影响。方法符合该研究入选标准的急性冠脉综合征患者120例,随机分成常规治疗者为对照组(n=60),常规治疗基础上加用倍他乐克者为治疗组(n=60),从小剂量开始,缓慢增加剂量,于第4周末行24 h动态心电图检查,比较两组HRV各项时域指标和心律失常发生率。结果治疗4周后,治疗组和对照组间HRV的SDNN、SDANN、PNN50、rMSSD比较,差异有统计学意义(P<0.05),心律失常发生率少于对照组(P<0.05)。结论在常规治疗的基础上,加用倍他乐克治疗急性冠脉综合征,提高HRV,减少心律失常发生率。
Objective To investigate the effect of Betaloc on autonomic nervous system in patients with acute coronary syndrome. Methods A total of 120 acute coronary syndrome patients were enrolled in this study. The patients were randomly divided into routine treatment (n = 60) and metoprolol (n = 60) on the basis of routine treatment. From the beginning of the small dose, the dose was slowly increased. At the end of the 4th week, the dynamic electrocardiogram was performed 24 hours. The time-domain indexes of HRV and arrhythmia incidence were compared between the two groups. Results After 4 weeks of treatment, there were significant differences in SDNN, SDANN, PNN50 and rMSSD between the treatment group and the control group (P <0.05). The incidence of arrhythmia was less than that of the control group (P <0.05). Conclusion On the basis of routine treatment, Betaloc can be used to treat acute coronary syndrome, improve HRV and reduce the incidence of arrhythmia.