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目的评价缬沙坦对轻-中度原发性高血压早期肾损害的疗效。方法200例轻-中度原发性高血压患者,分别检测血清半胱氨酸蛋白酶抑制剂(Cyst-C)及血清肌酐(Scr),筛选出有早期肾损害者50例(血清Cyst-C升高,而Ser正常);用缬沙坦80mg/d治疗8周,比较治疗前后血压及血清Cyst-C、Scr水平。结果缬沙坦治疗后血压及血清Cyst-C较治疗前明显下降(P<0.01),但Scr变化不明显(P>0.05)。结论血清Cyst-C对轻-中度原发性高血压的肾损害的敏感性优于Scr,缬沙坦降压的同时能改善轻-中度原发性高血压早期肾损害。
Objective To evaluate the effect of valsartan on early renal damage in mild to moderate essential hypertension. Methods Serum cystatin C (Cyst-C) and serum creatinine (Scr) were detected in 200 patients with mild-moderate essential hypertension. Fifty patients with early renal damage (serum Cyst-C Elevated, Ser normal); valsartan 80mg / d treatment for 8 weeks, before and after treatment of blood pressure and serum Cyst-C, Scr levels. Results After treatment with valsartan, blood pressure and serum Cyst-C were significantly lower than those before treatment (P <0.01), but Scr did not change significantly (P> 0.05). Conclusion Serum Cyst-C is more sensitive to renal damage in patients with mild to moderate essential hypertension than valsartan. In the meantime, valsartan can reduce blood pressure and improve early renal damage in patients with mild to moderate essential hypertension.