论文部分内容阅读
糖酵解系加速酶中的丙酮酸激酶有M型与L型同功酶两大类。M型又分为M_1与M_2亚型。M_1型分布于心肌、骨胳肌、脑组织;M_2型分布于脑、部分肝脏以及其他组织中。L型则存在于肝、肾、红细胞内。L型不稳定,在肝炎和其他肝脏疾病时未检出其明显增高。有关急性心肌梗塞时丙酮酸激酶增高的报道很少,与其他心肌酶比较其诊断意义的报告几无。为此,作者对60例健康成人,41例急性心肌梗塞(男36例,女5例),6例充血性心力衰竭(心瓣病3例,陈旧性心肌梗塞3例),5例安静型心绞痛,4例心肌炎,9例其它疾病(心律失常3例,脑血管意外3例,甲状腺机能减退2例,输尿管结石1例)以及选择性冠状动脉造影者20例进行了血浆PK(丙酮酸激酶)、CPK(肌酸磷酸激酶)、GOT(谷草转氨酸)、LDH(乳酸脱氢酶)和HBD(α-羟丁酸脱氢酶)测定。60例健康人取空腹血测定,以确定PK正常值。急性心肌梗塞病例从入院即刻起
Acceleration of glycolytic enzymes pyruvate kinase M-type and L-type two types of isozymes. M-type is divided into M_1 and M_2 subtypes. M_1 type distribution in the myocardium, skeletal muscle, brain tissue; M_2 distribution in the brain, part of the liver and other tissues. L-type is present in the liver, kidney, red blood cells. L-type instability in hepatitis and other liver diseases was not detected significantly increased. There are few reports of elevated pyruvate kinase in acute myocardial infarction and few in comparison with other myocardial enzymes in terms of their diagnostic significance. To this end, the author of 60 healthy adults, 41 cases of acute myocardial infarction (36 males and 5 females), 6 cases of congestive heart failure (valvular disease in 3 cases, 3 cases of old myocardial infarction), 5 cases of silent Angina pectoris, 4 cases of myocarditis, 9 other diseases (3 cases of arrhythmia, 3 cases of cerebrovascular accident, 2 cases of hypothyroidism and 1 case of ureteral calculi) and 20 cases of selective coronary angiography. Plasma PK (pyruvate kinase ), CPK (creatine phosphokinase), GOT (aspartate aminotransferase), LDH (lactate dehydrogenase), and HBD (alpha-hydroxybutyrate dehydrogenase). 60 healthy subjects take fasting blood test to determine the normal PK. Acute myocardial infarction cases from the moment of admission