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目的:观察小剂量红霉素联用金双歧治疗新生儿胃肠功能障碍的临床疗效。方法:119例患儿随机分成两组,对照组(59例)在常规治疗的基础上给予红霉素3～5 mg.kg-1.d-1泵入,观察组(60例)在对照组的基础上加用金双歧管饲,比较两组患儿胃液清亮时间、腹胀消失时间、胃潴留消失时间。结果:观察组患儿的胃液清亮时间、腹胀消失时间、胃潴留消失时间均明显短于对照组患儿,差异有统计学意义(P<0.01),所有患儿未出现不良反应。结论:小剂量红霉素联用金双歧治疗新生儿胃肠功能障碍比单用小剂量红霉素疗效更佳。
Objective: To observe the clinical efficacy of low dose erythromycin combined with gold bifid in the treatment of neonatal gastrointestinal dysfunction. Methods: One hundred and nineteen children were randomly divided into two groups. The control group (59 cases) was given erythromycin 3 ~ 5 mg.kg-1.d-1 on the basis of routine treatment. The observation group (60 cases) Based on the group with gold bifurcation feeding, compared with two groups of children gastric juice clear time, disappearance of abdominal distension time, disappearance of gastric retention time. Results: The clear time of gastric juice, the disappearance of bloating and the disappearance of gastric retention in observation group were significantly shorter than those in control group (P <0.01). No adverse reaction was found in all children. Conclusion: The low dose of erythromycin combined with bifidobacterium treatment of neonatal gastrointestinal dysfunction than single dose of erythromycin better effect.