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目的 探讨原发性高血压患者血浆肾上腺髓质素(ADM)水平的变化及其临床意义。方法 用放射免疫法测定46例原发性高血压患者与20例健康对照者的血浆ADM水平,并分析其血浆ADM与血清肌酐水平的关系。结果 原发性高血压患者血浆ADM水平显著高于对照组;原发性高血压伴肾功能损害组血浆ADM水平显著高于肾功能正常组;原发性高血压患者血浆ADM水平与血清肌酐水平呈显著性正相关(r=0. 41,P<0. 01)。结论 原发性高血压患者血浆ADM水平显著升高,且与肾功能损害进展有关。
Objective To investigate the changes of plasma adrenomedullin (ADM) in patients with essential hypertension and its clinical significance. Methods Plasma ADM levels in 46 patients with essential hypertension and 20 healthy controls were determined by radioimmunoassay. The relationship between plasma ADM and serum creatinine was analyzed. Results The plasma ADM level in patients with essential hypertension was significantly higher than that in the control group. The levels of plasma ADM in patients with essential hypertension and renal dysfunction were significantly higher than those in patients with normal renal function. The levels of plasma ADM and serum creatinine There was a significant positive correlation (r = 0.41, P <0.01). Conclusion Plasma ADM levels in patients with essential hypertension are significantly increased, and are associated with the progression of renal dysfunction.