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目的观察米非司酮配伍依沙吖啶在中期妊娠引产中的应用效果。方法选择2011年8月-2012年8月在习水县计划生育与妇幼保健中心引产的中期妊娠孕妇60名,随机分为观察组和对照组各30名。观察组口服米非司酮50 mg,1次/12 h,服用3次,服药前后2 h禁食,首次服药2 h后行羊膜腔内注射依沙吖啶100 mg。对照组直接行羊膜腔内注射依沙吖啶100 mg。比较两组引产成功率、软产道损伤情况和胎盘胎膜残留情况。计数资料采用χ2检验,P<0.05为差异有统计学意义。结果两组引产成功率均为100.00%。软产道损伤情况观察组3.33%,对照组23.33%;胎盘胎膜残留情况观察组36.67%,对照组80.00%。两组比较差异均有统计学意义(均P<0.05)。结论米非司酮配伍依沙吖啶用于中期妊娠引产成功率高、并发症少,值得在临床上推广应用。
Objective To observe the effect of mifepristone combined with ethacridine in induction of labor during second trimester pregnancy. Methods Sixty pregnant women of mid-term pregnancy who induced labor in Family Planning and MCH Center of Xishui County from August 2011 to August 2012 were randomly divided into observation group and control group with 30 in each. The observation group was treated with mifepristone 50 mg once daily for 12 h and 3 times fasting before and after taking the medicine for 2 h. The amniotic fluid was injected into the amniotic cavity 100 mg 2 hours after the first administration. The control group received amniotic fluid injection of amniotic fluid 100 mg directly. The success rate of induction of labor, the injury of soft birth canal and the residual of fetal membranes were compared between the two groups. Count data using χ2 test, P <0.05 for the difference was statistically significant. Results The success rate of induction of labor in both groups was 100.00%. The incidences of soft birth canal injury were 3.33% in the observation group and 23.33% in the control group; 36.67% in the observation group of residual fetal membranes and 80.00% in the control group. The differences between the two groups were statistically significant (P <0.05). Conclusion The combination of mifepristone and ethacridine for middle-term pregnancy has a high success rate of induction of labor and few complications, which is worth popularizing in clinic.