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目的探讨血清高敏C反应蛋白(hs-CRP)、血尿酸(UA)与高血压合并2型糖尿病患者颈动脉硬化的相关关系。方法选择108例高血压合并2型糖尿病患者,行颈动脉超声检查,按颈动脉超声结果分为内膜正常组、内膜增厚组和斑块形成组。测定入选患者血清hs-CRP、UA、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等指标,并对三组进行比较,分析颈动脉硬化与hs-CRP、UA的相关关系。结果随颈动脉硬化程度的加重,血清hs-CRP、UA水平逐渐升高,三组比较均有统计学差异(P<0.05),Spearman相关分析显示,hs-CR、UA均与颈动脉内膜中层厚度(IMT)成正相关。结论高血压合并2型糖尿病患者颈动脉硬化与血清hs-CRP、UA相关。
Objective To investigate the relationship between serum high-sensitivity C-reactive protein (hs-CRP), serum uric acid (UA) and carotid atherosclerosis in type 2 diabetic patients with hypertension. Methods A total of 108 hypertensive patients with type 2 diabetes mellitus were selected and underwent carotid ultrasonography. According to the results of carotid artery ultrasound, they were divided into normal intima, thickening intima and plaque formation. Serum levels of hs-CRP, UA, TG, TC, HDL-C and LDL-C in the selected patients were determined. Group were compared to analyze the correlation between carotid atherosclerosis and hs-CRP, UA. Results With the severity of carotid atherosclerosis, serum hs-CRP and UA levels gradually increased, the three groups were statistically significant (P <0.05), Spearman correlation analysis showed that hs-CR, UA and carotid intima Middle thickness (IMT) was positively correlated. Conclusions Carotid atherosclerosis is associated with serum hs-CRP and UA in patients with hypertension and type 2 diabetes mellitus.