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目的观察牙周病患者应用不同药物进行分组治疗,从而观察5-硝基咪唑类药物对牙周病患者的临床应用治疗效果,为临床治疗牙周病提供更为可靠的依据。方法两组患者均给与牙周病常规治疗措施。观察组患者在常规治疗的基础上给予口服甲硝唑片剂治疗;对照组患者在常规治疗的基础上给予口服四环素片剂进行治疗。观察两组患者的治疗结果并进行统计学分析。结果观察组患者应用5-硝基咪唑类药物对牙周病进行治疗后,其总有效率为93.75%,明显高于对照组患者应用四环素进行治疗后的总有效率75.00%,且P<0.05,差异具有统计学意义。结论 5-硝基咪唑类药物是目前应用较为广泛的抗厌氧菌药物,也将成为临床抗厌氧微生物感染的首选药物。
Objective To observe the clinical effect of 5-nitroimidazole on patients with periodontal disease and to provide a more reliable basis for clinical treatment of periodontal disease. Methods Two groups of patients were given routine treatment of periodontal disease. Patients in the observation group were treated with oral metronidazole tablets on the basis of routine treatment; patients in the control group were treated with oral tetracycline tablets on the basis of conventional treatment. The results of the two groups of patients were observed and statistically analyzed. Results In the observation group, the total effective rate was 93.75% after 5-nitroimidazole treatment of periodontal disease, which was significantly higher than that of the control group (75.00%, P <0.05) after treatment with tetracycline , The difference was statistically significant. Conclusions 5-nitroimidazole is the most widely used anti-anaerobic drug and will be the drug of choice for clinical anti-anaerobic microbial infections.