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由荚膜组织胞浆菌引起的感染是一种肉芽肿性疾病。喉组织胞浆菌病并非罕见,但它酷似癌瘤,诊断困难。作者报告一例男性患者,69岁。主诉声哑,吞咽、呼吸困难及体重减轻三个月。直接喉镜检查发现会厌喉面有一巨大肿物,已波及左杓会厌皱襞、声带及杓状软骨间,左声带固定。经反复活检报告为慢性炎症伴肉芽肿;涂片找到荚膜组织胞浆菌。给予二性霉素B 治疗,总量1.5gm,4～6周肿物消退,随诊二年未再发。组织胞浆菌病在全世界分布很广,但以美国俄亥俄和密西西比河流域为主要流行区,该区有
Infection caused by capsular histoplasmosis is a granulomatous disease. Laryngeal histoplasmosis is not uncommon, but it resembles a cancerous lesion, making diagnosis difficult. The authors report a male patient, aged 69. The main complaint dumb, swallowing, difficulty breathing and weight loss for three months. Direct laryngoscopy found epiglottis throat surface has a huge tumor, has spread to the left cradle epiglottis, vocal fold and arytenoid cartilage, left vocal cords fixed. After repeated biopsies reported chronic inflammation with granuloma; smear found capsule histoplasma. Give amphotericin B treatment, the total amount of 1.5gm, 4 to 6 weeks of tumor regression, no recurrence of two years follow-up. Histoplasmosis is widespread throughout the world, but is dominated by the Ohio and Mississippi River basins in the United States