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目的:探析狼疮性肾炎应用来氟米特及泼尼松联合治疗的疗效和安全性。方法:选取我院于2011年12月~2012年12月收治的100例狼疮性肾炎患者作为观察对象,随机将其分为观察组与对照组,对照组患者应用环磷酰胺联合泼尼松治疗,观察组患者应用来氟米特联合泼尼松治疗,观察比较两组患者的治疗效果。结果:观察组患者有效率为90%,明显较对照组66%的有效率高,比较差异有统计学意义(P<0.05),治疗后两组患者的红细胞沉降率、24h尿蛋白定量、C反应蛋白均有明显降低,观察组患者下降幅度较大,与对照组比较差异有统计学意义(P<0.05)。结论:狼疮性肾炎患者应用来氟米特联合泼尼松治疗有良好的应用效果,且不良反应发生少,可以在临床上广泛推广。
Objective: To investigate the efficacy and safety of leflunomide combined with prednisone in the treatment of lupus nephritis. Methods: 100 cases of lupus nephritis treated in our hospital from December 2011 to December 2012 were selected as the observation object and randomly divided into observation group and control group. Patients in the control group were treated with cyclophosphamide combined with prednisone The patients in the observation group were treated with leflunomide and prednisone, and the treatment effect was observed and compared between the two groups. Results: The effective rate of observation group was 90%, which was significantly higher than that of 66% of control group (P <0.05). After treatment, the erythrocyte sedimentation rate, 24h urinary protein, C Reaction protein were significantly reduced, the observation group patients decreased significantly, compared with the control group, the difference was statistically significant (P <0.05). Conclusion: The application of leflunomide combined with prednisone has a good effect in patients with lupus nephritis, and the incidence of adverse reactions is small, which can be widely popularized clinically.